Field-Assisted Biofabrication
Field-Assisted Biofabrication (FAB) team, focuses on advancing the engineering of living systems using extrinsic fields-based biofabrication technologies, such as hydrodynamic waves, magnetic fields, light, and stimuli-responsive materials for modelling and regeneration.
Our team leverages FAB approaches to spatially pattern and assemble cells, aggregates, organoids, and extracellular matrices in a controlled and programmed manner, with the goal of creating advanced human in vitro models, in alignment with the 3Rs philosophy.
One of the key innovations developed by our team is Sound Induced Morphogenesis (SIM), a novel technology that enables contactless bioassembly, under fast and mild culture conditions, by hydrodynamic waves, opening new frontiers for functional and morphologically relevant tissue generation. In 2020, SIM technology was licensed to mimiX Biotherapeutics, a successful Swiss startup that is now advancing in clinical translation. SIM was selected as part of the “Technology Outlook 2023” by the Swiss Academy of Engineering Sciences, SATW. Implants from a loudspeaker: Technology Outlook
Selected collaborative projects
- PREMUROSA, H2020 MSCA – ITN 2019 "Precision medicine for musculoskeletal regeneration, prosthetics, and active ageing"
- FLAMIN-GO, H2020-NMBP-TR-IND, "From pathobiology to synovia on chip: driving rheumatoid arthritis to the precision medicine goal"
- E - RegenMed2.0, Eurostar, EU
- STRATAGEM New diagnostic and therapeutic tools against multidrug resistant tumours. Cost Action1710
Selected scientific publications
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[1] A Stimuli-Responsive Nanocomposite for 3D Anisotropic Cell-Guidance and Magnetic Soft Robotics. Adv. Funct. Mater.10.1002/adfm.201804647 |
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[2] A Multifunctional Nanocomposite Hydrogel for Endoscopic Tracking and Manipulation Adv. Int. Syst. 2019 10.1002/aisy.202070031 |
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[3] Sound-induced morphogenesis of multicellular systems for rapid orchestration of vascular networks Biofabrication 2021 10.1088/1758-5090/abbb9c |
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[4] Sound-based assembly of three-dimensional cellularized and acellularized constructs 2023 Mat Today Bio 10.1016/j.mtbio.2023.100775
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[5] Engineering Sensory Ganglion Multicellular System to Model Tissue Nerve Ingrowth Adv Science 2023 https://doi.org/10.1002/advs.202308478
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[6] Differential proteomics profile of microcapillary networks in response to sound pattern-driven local cell density enhancement Biomat & Biosyst. 2024 10.1016/j.bbiosy.2024.100094
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[7] Sound-Based Assembly of Magnetically Actuated Soft Robots Toward Enhanced Release of Extracellular Vesicles Adv. Int. Syst.2024 10.1002/aisy.202400437
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