Clinical Evidence

As part of the AO Innovation Translation Center (ITC), Clinical Evidence conducts clinical research in accordance with global standards (ISO 14155 and ICH GCP). Adhering to a strict standard of data analysis, the AO ITC ensures the delivery of unbiased clinical evidence to serve the medical community. The AO ITC Clinical Science Advisory Commission (CSAC ) provides strategic advice for clinical evidence generation.


AO ITC Clinical Evidence: The AO’s commitment to patient care through unbiased evidence 

As the AO's clinical research provider, we are a team of about 30 clinical research specialists in Medical Scientific Affairs (medical advisers) and Clinical Operations (project managers, medical statisticians, medical writers, data mangers, clinical research associates, study assistants, image research associates, and quality and regulatory managers). 
Guided by leading surgeons, we conduct clinical research on highly relevant trauma and orthopedics topics to produce clinical evidence for better patient care.

AO Innovation Translation Center - Clinical Operations

What we do

Current studies

Find out more about the AO ITC’s studies.

Completed studies

We transform ideas into clinical study protocols. AO clinical studies are divided into 5 phases: idea, planning, execution, analysis, and publication.


Peer-reviewed publications

Browse our publications from 2013 on.

Clinical Research Fellowship

Apply now to take part in a clinical research fellowship at the AO's Innovation Translation Center.

Meet the team

“The AO Technical Commission is unique because it is a place where you have very innovative people coming together and trying to come up with solutions to very complex problems.”

Daniel Buchbinder

Clinical evidence: Central to the AO's history

In 1959, Maurice E Müller, a founding member of the AO Foundation, created the AO Documentation Center to share experience and validate the AO methods. In 1967, the AO Documentation Center was formally registered in Bern, Switzerland, as a foundation for the purpose of collecting, analyzing, and evaluation of fracture handling/osteosyntheses.

In 1995, the AO Documentation Center was registered in Canton Graubünden and renamed AO Documentation and Publishing Foundation. Today, this is an essential part of the AO Innovation Translation Center.