Tissue engineering and cell biology
Developing novel trauma repair treatments within the musculoskeletal system
Cell and tissue culture
- Cell isolation (eg, osteoblasts, chondrocytes, stem cells) from various tissues (eg, bone, cartilage, disc, veins, bone marrow, peripheral blood) and from various species (eg, human samples, bovine, sheep, rat)
- Tissue biopsies from various locations and species (eg, cartilage and intervertebral disc)
- Two-dimensional and threedimensional cell culture
- Differentiation of precursor or stem cells in specific cell types (eg, osteoblasts or chondrocytes)
- Bioreactor culture systems for intervertebral disc (organ culture) and articular cartilage (pin-on-ball)
- Gene transfer: non-viral and viral
Analysis
- Gene expression
- Isotope incorporation
- Biochemical analysis (eg, glycosaminoglycan, DNA, alkaline phosphatase)
- Cell viability
- Time lapse microscopy
- Protein analysis
- Fluorescence Activated Cell Sorting
- Biomarker screening
Polymer Processing and Characterization
- 3-D Printing, biofabrication, scaffold, film and membrane processing
- Gel permeation chromatography, viscosimetry, thermal analysis, trace analysis, in vitro degradation, contact angle, hydrolytic permeability, rheology
![](/-/media/project/aocd/aof/what-we-do/research-innovation/cro-services-and-resources/tissue-engineering-and-cell-biology/ari_promo_services_5tissue_2_900x506.png?h=506&iar=0&w=900&hash=26E11DFDA1607D30954E6B6AD5D025F1)
Cartilage bioreactor for cell-seeded scaffolds and osteochondral explants
![](/-/media/project/aocd/aof/what-we-do/research-innovation/cro-services-and-resources/tissue-engineering-and-cell-biology/ari_promo_services_5tissue_1_900x506.png?h=506&iar=0&w=900&hash=3EEC11614C7E1C601F28CD436027C94F)
3D printed bioink
Qualifications
- Experienced scientists (PhD) supervise studies
- Multidisciplinary team (biologists, chemists, engineers, medical fellows)
- Highly qualified technicians with up to 25 years experience
Certification
- ISO 9001
Contact
![](/-/media/project/aocd/aof/what-we-do/research-innovation/cro-services-and-resources/aof_ari_portrait_staff_bentz_ulrich_600x600.jpg?h=180&iar=0&w=180&hash=1E04D4E7253B24740DC4D339CBB20C6B)
Ulrich Bentz
AO Research Institute Davos
Clavadelerstrasse 8
7270 Davos Platz
Switzerland
Tel.: +41 81 414 23 26