Clinical Evidence Current Studies
Current studies in 2021
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AO Trauma
Short title Project title
Principal coordinating investigator
Project ending
Current phase
PPFx Registry
Multicenter prospective registry for periprosthetic fractures after hip or knee arthroplasty
Karl Stoffel
2023
Monitoring
CPP Patient Outcome Project I
Clinical Priority Program (CPP) Patient Outcome Project I:
Translation, Cultural Adaptation and Cognitive Debriefing of Extension Items of PROMIS Physical Function item bank V2.0 in German and SpanishMarilyn Heng, Claudia Hartmann
2024
Planning
CPP Patient Outcome Project II
Clinical Priority Program (CPP Patient Outcome Project II:
GO FIT FAST - Gait Observation for Fully Individualized Treatment and Aftercare following Surgery and TraumaTim Pohlemann, Benedikt Braun
2024 Monitoring
CPP Patient Outcome Project III
Clinical Priority Program (CPP) Patient Outcome Project III:
Development of interpretation guidance for clinicians to better understand meaning of PROMIS scoresPrakash Jayakumar, Marilyn Heng, Stephen Gwilym
2024
Monitoring
CPP Patient Outcome Project IV
Clinical Priority Program (CPP) Patient Outcome Project IV:
Linking of PROMIS Physical Function to Legacy Measures in an Orthopaedic Patient PopulationMarilyn Heng (center 1),
Tim Pohlemann, Benedikt Braun (Center 2), Prakash Jayakumar (Center 3)2024
Monitoring
CPP Patient Outcome Project V
Clinical Priority Program (CPP) Patient Outcome Project V:
Norm Data - Collection of international Age-based Norm Data for interpretation of scores obtained from the newly extended PROMIS® Physical Function item bank version 2.0Matthias Rose
2024
Monitoring
CPP Patient Outcome Project VI
Clinical Priority Program (CPP) Patient Outcome Project VI:
Standard setting to develop PROMIS score severity threshold categoriesMarilyn Heng
2024
Monitoring
AOFFP Fragility Fractures of the Pelvis: Observational Outcome Study Pol Maria Rommens 2024 Monitoring PedOrtho A prospective multicenter observational registry of pediatric orthopedic trauma and health outcomes in skeletally immature children Kishore Mulpuri 2026 Monitoring -
AO Spine
Short title Project title
Principal coordinating investigator
Project ending
Current phase
EPOSO The epidemiology, process and outcomes of spine oncology
Charles Fisher
2022
Publication
SDIM
Spinal deformity intraoperative monitoring: understanding and managing intraoperative neuromonitoring changes during spinal deformity surgery
Stephen Lewis
2022
Monitoring
PEEDS Prospective evaluation of elderly deformity surgery
Stephen Lewis
2022
Analysis
MTRON
Metastatic tumor research and outcomes network: a multicenter prospective registry for the management of metastatic spine tumors
Charles Fisher
2024
Monitoring
PTRON
Primary tumor research and outcomes network: A multicenter prospective registry for the management of primary tumors of the spine
Jeremy Reynolds
2024
Monitoring
DegenPRO
Spine registry to collect outcome measures related to the disease status of patients with dpine disorders
Tim Yoon
2024
Monitoring
Spine_TL-A3-A4
Thoracolumbar burst fractures (AOSpine A3, A4) in neurologically intact patients: an observational, multicenter cohort study comparing surgical versus non-surgical treatment
Marcel Dvorak
2022
Monitoring
SCI POEM
Prognostic factors and therapeutic effects of surgical treatment for traumatic spinal column iInjury with spinal cord injury
Allard Hosman
2022
Publication
INTWIN Traumatic incomplete tetraplegia without instability: a prospective multicenter feasibility study of outcomes and prognosis
Jefferson R Wilson
2026
Planning
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AO CMF
Short title Project title
Principal coordinating investigator
Project ending
Current phase
MRONJ registry
An international, multicenter, prospective registry to collect data of treatment patterns of patients with Medication-Related OsteoNecrosis of the Jaw (MRONJ) and their outcome
Risto Kontio (University of Helsinki) and Sven Otto (Ludwig-Maximilian University, Munich)
2024
Monitoring
BCFx registry
International, multicenter, prospective registry to collect data of treatment patterns in patients with bilateral condylar fracture (BCFx) of the mandible
Risto Kontio (University of Helsinki) and Edward Ellis 3rd (University of Texas Health Science Center at San Antonio)
2024
Monitoring
OFx
International, multicenter, prospective registry to collect data on orbital fractures (OFx), their treatment and outcome
Eppo B Wolvius
2026
Monitoring
MFx 60+
International, multicenter, prospective registry to collect data in patients > 60 years suffering from mandibular fractures
Risto Kontio
2025
Monitoring
TMJ replacements International, multicenter, prospective registry to collect data of patients treated with alloplastic temporomandibular joint (TMJ) replacements
Andreas Thor
2028
Monitoring
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AO Technical Commission
Short title Project title
Principal coordinating investigator
Project ending
Current phase
TROLLEY
Evaluation of a growth guiding construct vs. standard dual growing rods and VEPTR for the treatment of early onset scoliosis patients: A prospective multi-center cohort study with a matched historical control.
Jean Ouellet, MD, FRCSC
2029 Monitoring
FR Tomofix
A focused registry on the conservative treatment of osteoarthritis of the knee
Takeshi Sawaguchi
Q4 2022 Publication Moticon - HTO
OpenGo Sensor Insole in open wedge HTO
Stefan Döbele, Steffen Schröter
Q3 2022 Monitoring
PedFemFx
A prospective multicenter observational registry for children up to 16 years of age with femur shaft fractures
Peter Schmittenbecher, Unni Narayanan
Q2 2022 Monitoring
FR FNS
A focused registry on the Femoral Neck System (FNS) in patients with femoral neck fractures
Karl Stoffel
Q2 2022 Publication
EPOCA
A randomized multicenter study comparing the effectiveness of hemi versus total shoulder arthroplasty in patients with a degenerative joint disease
Norbert Suedkamp
Q2 2022 Monitoring
PPFx Registry
Multicenter prospective registry for periprosthetic fractures after hip or knee arthroplasty
Karl Stoffel
2023 Monitoring
VA-LCP Case review
Locking plates for distal femur fractures – a multicenter case review
A retrospective radiological analysis of the mechanical performance of different locking plates in distal femoral fracturesMark Lee
2022
Monitoring
LoBoDeRe
An international, multicenter, prospective registry to investigate treatment options and their outcomes on Long Bones Defects
Christoph Pape
Q2 2026 Planning
FROST
Fracture-Related Outcome Study for operatively treated Tibia shaft fractures
Willem-Jan Metsemakers
Q4 2024 Monitoring
CMF distractor
Multicenter registry on indications, safety and clinical outcome of internal univector and curvilinear distraction devices in the treatment of congenital and acquired deformities of the craniomaxillofacial (CMF) skeleton
Richard A Hopper
Q4 2025 Planning SMDR Registry International, multicenter, prospective registry to collect data on treatment, outcome, and complications subsequent to reconstruction of acquired segmental mandibular defects in oral squamous cell carcinoma patients - SMDR (Segmental Mandibular Defect Reconstruction) registry
Rüdiger M Zimmerer
Q1 2027 Planning MatrixWAVE
An International, Multicenter, Focused Registry to collect clinical data on the MatrixWAVE Mandibulo-Maxillary Fixation System
Carl-Peter Cornelius
Q2 2023 Monitoring
VA Clavicle Observational case series on the clinical performance of the DePuy Synthes Variable Angle Clavicle Plate and Clavicle Hook Plate 2.7 Systems
Simon Lambert 2025
Planning
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AO Education Institute
Short title Project title
Principal coordinating investigator
Project ending
Current phase
Immpact Development of performance metrics for cephalomedullary nailing for unstable pertrochanteric fractures- phase 1
Anthony Gallagher
n/a
Montoring
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AO Development Incubator
Short title Project title
Principal coordinating investigator
Project ending
Current phase
Fracture Monitor Prospective case series to analyze safety data in femoral and proximal tibial fracture patients treated with a locking compression plate with an attached investigational Fracture Monitor (Fracture Monitor-Femur/Proximal Tibia)
Bendikt Braun
n/a
Planning
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Collaboration with the AO Research Institute Davos (ARI)
Short title Project title
Principal coordinating investigator
Project ending
Current phase
SmartPlate
Next generation SmartFix-integration with implants
n/a
n/a
Idea
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Completed studies
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Clinical Science
Clinical evidence generated through AO clinical studies can be accessed in the form of journal articles, presentations at scientific meetings, final study reports, guidelines, classifications, and/or news on the AO website.