Clinical Evidence Current Studies

Find out more about the 45 studies we are currently running in 40 countries.

Current studies

  • AO Trauma
    Short title 

    Project title

    Principal coordinating investigator

    Project ending

    Current phase

    PPFx Registry

    Multicenter prospective registry for periprosthetic fractures after hip or knee arthroplasty

    Karl Stoffel

    2023

    Monitoring

    CPP Patient Outcome Project I

    Clinical Priority Program (CPP) Patient Outcome Project I:
    Translation, Cultural Adaptation and Cognitive Debriefing of Extension Items of PROMIS Physical Function item bank V2.0 in German and Spanish

    Marilyn Heng, Claudia Hartmann

    2024

    Publication

    CPP Patient Outcome Project II

    Clinical Priority Program (CPP Patient Outcome Project II:
    GO FIT FAST - Gait Observation for Fully Individualized Treatment and Aftercare following Surgery and Trauma

    Tim Pohlemann, Benedikt Braun

    2029

    Monitoring

    CPP Patient Outcome Project III

    Clinical Priority Program (CPP) Patient Outcome Project III:
    Development of interpretation guidance for clinicians to better understand meaning of PROMIS scores

    Prakash Jayakumar, Marilyn Heng, Stephen Gwilym

    2029

    Monitoring

    CPP Patient Outcome Project IV

    Clinical Priority Program (CPP) Patient Outcome Project IV:
    Linking of PROMIS Physical Function to Legacy Measures in an Orthopaedic Patient Population

    Marilyn Heng (center 1),
    Tim Pohlemann, Benedikt Braun (Center 2), Prakash Jayakumar (Center 3)

    2029

    Monitoring

    AOFFP Fragility Fractures of the Pelvis: Observational Outcome Study Pol Maria Rommens 2029 Monitoring
    PedOrtho A prospective multicenter observational registry of pediatric orthopedic trauma and health outcomes in skeletally immature children Kishore Mulpuri 2028 Monitoring
    (COSTA 2) Two-stage development of a Core Outcome Set for distal tibia and ankle fractures. COSTA 2, the second stage, seeks to identify the best suitable outcome measurement systems attributed to the defined core domain sets Kirstie Haywood 2025 Planning
  • AO Spine
    Short title 

    Project title

    Principal coordinating investigator

    Project ending

    Current phase

    EPOSO

    The epidemiology, process and outcomes of spine oncology

    Charles Fisher

    2024

    Publication

    SDIM

    Spinal deformity intraoperative monitoring: understanding and managing intraoperative neuromonitoring changes during spinal deformity surgery

    Stephen Lewis

    2023

    Analysis

     PEEDS

    Prospective evaluation of elderly deformity surgery

    Stephen Lewis

    2025

    Analysis

    MTRON

    Metastatic tumor research and outcomes network: a multicenter prospective registry for the management of metastatic spine tumors

    Charles Fisher

    open ended registry

    Monitoring

    PTRON

    Primary tumor research and outcomes network: A multicenter prospective registry for the management of primary tumors of the spine

    Jeremy Reynolds

    open ended registry

    Monitoring

    DegenPRO

    Spine registry to collect outcome measures related to the disease status of patients with dpine disorders

    Tim Yoon

    2024

    Monitoring

    Spine_TL-A3-A4

    Thoracolumbar burst fractures (AOSpine A3, A4) in neurologically intact patients: an observational, multicenter cohort study comparing surgical versus non-surgical treatment

    Marcel Dvorak

    2025

    Analysis

    SCI POEM

    Prognostic factors and therapeutic effects of surgical treatment for traumatic spinal column iInjury with spinal cord injury

    Allard Hosman

    2025

    Publication

    INTWIN

    Traumatic incomplete tetraplegia without instability: a prospective multicenter feasibility study of outcomes and prognosis

    Jefferson R Wilson

    2027

    Planning

    I-SCRIBBLE
    Spinal Cord Injury Blood Biomarker Longitudinal Evaluation
    Brian K. Kwon
    2028 Idea
    SMART
    Durability of supplementary rod constructs—SuppleMentAry Rod Technique (SMART)—for long-segment posterior instrumented spinal fusion procedures: A multicenter retrospective comparative study with dual-rod constructs
    Justin Smith
    2027 Planning
    TL Ofx
    The osteoporotic fracture classification-based scoring system for treatment decision in thoracolumbar osteoporotic fractures: An international multicenter prospective study
    Klaus Schnake
    2028 Idea
  • AO CMF
    Short title 

    Project title

    Principal coordinating investigator

    Project ending

    Current phase

    MRONJ registry

    An international, multicenter, prospective registry to collect data of treatment patterns of patients with Medication-Related OsteoNecrosis of the Jaw (MRONJ) and their outcome

    Risto Kontion, Sven Otto 

    2026

    Monitoring

    BCFx registry

    International, multicenter, prospective registry to collect data of treatment patterns in patients with bilateral condylar fracture (BCFx) of the mandible

    Risto Kontio, Edward Ellis 3rd 

    2025

    Analysis

    OFx

    International, multicenter, prospective registry to collect data on orbital fractures (OFx), their treatment and outcome

    Eppo B Wolvius

    2029

    Monitoring

    TMJ replacements

    International, multicenter, prospective registry to collect data of patients treated with alloplastic temporomandibular joint (TMJ) replacements

    Andreas Thor

    2031

    Monitoring

  • AO Technical Commission
    Short title 

    Project title

    Principal coordinating investigator

    Project ending

    Current phase

    TROLLEY
    Evaluation of a growth guiding construct vs. standard dual growing rods and VEPTR for the treatment of early onset scoliosis patients: A prospective multi-center cohort study with a matched historical control.
     
    Jean Ouellet, MD, FRCSC
    2029 Monitoring
    Moticon - HTO

    OpenGo Sensor Insole in open wedge HTO

    Steffen Schröter

    Q2 2024             

    Monitoring

    PedFemFx

    A prospective multicenter observational registry for children up to 16 years of age with femur shaft fractures

    Peter Schmittenbecher, Unni Narayanan

    2024        

    Analysis

    FR FNS

    A focused registry on the Femoral Neck System (FNS) in patients with femoral neck fractures

    Karl Stoffel

    2024           

    Analysis

    EPOCA

    A randomized multicenter study comparing the effectiveness of hemi versus total shoulder arthroplasty in patients with a degenerative joint disease

    Norbert Suedkamp, Martin Jäger

    Q2 2024             

    Analysis

    PPFx Registry

    Multicenter prospective registry for periprosthetic fractures after hip or knee arthroplasty

    Karl Stoffel

    2028           

    Monitoring

    VA-LCP Case review
    Locking plates for distal femur fractures – a multicenter case review
    A retrospective radiological analysis of the mechanical performance of different locking plates in distal femoral fractures             

    Mark Lee

    2024

    Analysis

    LoBoDeRe

    An international, multicenter, prospective registry to investigate treatment options and their outcomes on Long Bones Defects

    Hans-Christoph Pape

    2029          

    Planning

    FROST

    Fracture-Related Outcome Study for operatively treated Tibia shaft fractures

    Willem-Jan Metsemakers

    2027             

    Monitoring

    SMDR Registry International, multicenter, prospective registry to collect data on treatment, outcome, and complications subsequent to reconstruction of acquired segmental mandibular defects in oral squamous cell carcinoma patients - SMDR (Segmental Mandibular Defect Reconstruction) registry
     
    Rüdiger M Zimmerer 2030 Monitoring
    MatrixWAVE
    An International, Multicenter, Focused Registry to collect clinical data on the MatrixWAVE Mandibulo-Maxillary Fixation System
     
    Carl-Peter Cornelius
    2025 Monitoring
    VA Clavicle Observational case series on the clinical performance of the DePuy Synthes Variable Angle Clavicle Plate and Clavicle Hook Plate 2.7 Systems
     
    Simon Lambert 2027
    Planning
  • AO Education Institute
    Short title 

    Project title

    Principal coordinating investigator

    Project ending

    Current phase

    Immpact

    Development of performance metrics for cephalomedullary nailing for unstable pertrochanteric fractures- phase 1

    Anthony Gallagher

    n/a

    Analysis

  • AO Development Incubator
    Short title 

    Project title

    Principal coordinating investigator

    Project ending

    Current phase

    Fracture Monitor

    Prospective case series to analyze safety data in femoral and proximal tibial fracture patients treated with a locking compression plate with an attached investigational Fracture Monitor (Fracture Monitor-Femur/Proximal Tibia)

    Bendikt Braun

    2026

    Monitoring

    (Image AI) Development of a high quality, annotated data set of proximal femur fractures (31A/31B/31C) to be used for development or testing of AI
    Alessandro Aprato
    2025 Monitoring
  • Collaboration with the AO Research Institute Davos (ARI)
    Short title 

    Project title

    Principal coordinating investigator

    Project ending

    Current phase

    SmartPlate

    Next generation SmartFix-integration with implants

    n/a

    n/a

    Idea

    Fracture Monitor
    Prospective first-in-human clinical investigation to evaluate the safety of the Fracture Monitor T1 in patients with femur fractures treated with a locking compression plate
    Bendikt Braun
    2026 Monitoring

Find out more

Clinical Research Fellowship

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Completed studies

We transform ideas into clinical study protocols. AO clinical studies are divided into 5 phases: idea, planning, execution, analysis, and publication.


Clinical Science

Clinical evidence generated through AO clinical studies can be accessed in the form of journal articles, presentations at scientific meetings, final study reports, guidelines, classifications, and/or news on the AO website.