Biomedical Materials

Materials and (bio)manufacturing methods to improve patient care in musculoskeletal disorders

 

Selected collaborative projects

  • 2020-2026- Establishment of the Baltic Biomaterials Centre of Excellence. (partner, H2020 funded project, number 857287). 
  • AOCMF Boost - Instructive bone regenerating hydrogel for translational bone repair, 2022-2026.
  • Leading House for the Middle East and North Africa for Research Partnership Grant “Space ImmunoBioInks” (RPG-2022-38) and Consolidation 2023 “SI-WHIM” (COG-2023-35).
  • Engineered full-organ 3D intervertebral disc as standardized model for studying disc degeneration and disease. (INDEED, coordinator SNF-ANR Bilateral project, nber: 310030E_189310)
  • 3D Printed-Matrix Assisted Chemically Modified RNAs Bone Regenerative Therapy for Trauma and Osteoporotic Patients. (cmRNAbone, H2020 funded project, nber: 874790).

 

Selected scientific publications

  • J.K. Wychowaniec, E.I. Bektas, A.J. Vernengo, M. Muerner, M. Airoldi, P.S. Tipay, J. Sapudom, J. Teo, D. Eglin, M. D'Este, Effect of molecular weight of tyramine-modified hyaluronan on polarization state of THP-1 and peripheral blood mononuclear cells-derived macrophages, Biomaterials Advances 169 (2025) 214166.
  • R. Randriantsilefisoa, M. D'Este, A chemical toolkit for the fabrication of antibacterial wet adhesives using one pot synthesis, Materials Today Chemistry 43 (2025) 102504.
  • G. Miklosic, S.J. Ferguson, M. D’Este, Engineering complex tissue-like microenvironments with biomaterials and biofabrication, Trends in Biotechnology 42(10) (2024) 1241-1257.
  • D. Van der Heide, L.P. Hatt, E. Della Bella, A. Hangartner, W.A. Lackington, H. Yuan, F. De Groot-Barrère, M.J. Stoddart, M. D'Este, Characterization and biological evaluation of 3D printed composite ink consisting of collagen, hyaluronic acid and calcium phosphate for bone regeneration, Carbohydrate Polymer Technologies and Applications 7 (2024) 100518.
  • A. Schwab, R. Levato, M. D’Este, S. Piluso, D. Eglin, J. Malda, Printability and Shape Fidelity of Bioinks in 3D Bioprinting. Chem. Rev. 2020.
  • A. Schwab, C. Helary, R. G. Richards, M. Alini, D. Eglin, M. D'Este, Tissue mimetic hyaluronan bioink containing collagen fibers with controlled orientation modulating cell migration and alignment. Materials Today Bio 100058 2020/6/1
  • D. Petta, U. D'Amora, L. Ambrosio, D. Grijpma, D. Eglin, M. D'Este, Hyaluronic acid as a (bio)ink for extrusion-based 3D printing, Biofabrication 12(3) (2020) 032001.
  • D. Petta, A.R. Armiento, D. Grijpma, M. Alini, D. Eglin, M. D'Este, 3D bioprinting of a hyaluronan bioink through enzymatic-and visible light-crosslinking, Biofabrication 10(4) (2018) 044104.
  • M. D'Este, D. Eglin, M. Alini, Lessons to be learned and future directions for intervertebral disc biomaterials, Acta Biomater 78 (2018) 13-22.

Other focus areas

Progenitor Cell Biology and Mechanoregulation

Disc and Cartilage Biology

Field-Assisted Biofabrication

Bone Biology

Infection Biology

Meet the team

See more about the team on the Regenerative Orthopaedics research program